Study of onset, progression and treatment of hematological and solid tumors, focusing on chronic lymphocytic leukemia, glioma, neuroblastoma, colorectal, pancreatic, ovarian and breast cancer
Analysis of the molecular mechanisms underlying glioma cells invasion and analysis of the immune escape mechanisms of glioma cells in a murine model of glioma progression
Scientists: Appolloni I., Ceresa D., Malatesta P.
Analysis of the intracellular signaling cross-talks induced by microenvironmental stimuli (B cell receptor, Toll-Like Receptor 9, CD40/CD40L pathway) modulating aggressiveness and development of relapse/refractory subclones in Chronic Lymphocytic Leukemia patients
Scientists: Mazzarello A.N., Cossu V.
In vitro and in vivo analysis of the effectiveness of photo- and sono-dynamic therapies in gliomas using recombinant phages as vectors to transport light- or ultrasound-activatable sensitizing molecules
Scientists: Appolloni I.
Morpho-functional characterization of antibody-drug conjugates (e.g., T-DXd) in HER2-positive and HER2-low breast cancers, with emphasis on subcellular trafficking, lysosomal and mitochondrial remodeling, stress responses and adaptive mechanisms of drug resistance
Scientists: Cortese K.
Identification and characterization of tumor associated antigens as target in immunotherapy
Scientists: Bottino C., Cantoni C., Carlomagno S., Castriconi R., Della Chiesa M., Dondero A., Marcenaro E., Pesce S., Sivori S., Spaggiari G.M.
Identification of glial cell subpopulations in tumors of the parasympathetic nervous system with single cell sequencing strategies. Study of their role in the maintenance of tumor growth
Scientists: Pagano A.
Role of non-coding RNAs in the differentiation and metastatic process of neuroblastoma and in vitro/in vivo drug induction of the over-expression of the non-coding RNA NDM29 and development of a drug combination for the treatment of high-risk neuroblastoma
Scientists: Pagano A.
Study of intratumoral competition at clonal scale and identification of nongenetic mechanisms underlying intraclonal variability in Glioblastoma
Scientists: Ceresa D., Malatesta P.
Development of methods of oncolytic immunovirotherapy. Assays of oncolytic Herpes Virus retargeted to tumor surface molecules and expressing stimulatory cytokines to induce anti-tumor immune response in mouse models of high grade gliomas
Scientists: Malatesta P.
Development of in vitro model of multiple myeloma and study of new pharmacological approaches
Personale coinvolto: Tavella S.
Evaluation and analysis of chemotherapy potentiation in triple negative breast cancer by combined treatments through drug repositioning
Scientists: Pagano A.