Analysis of the mechanisms underlying the onset, the maintenance, and the progression of Chronic Lymphocytic Leukemia (CLL) with a focus on the role of the Immunoglobulin and molecular networks that regulate cell survival, activation and proliferation 

Scientists: Bagnara D., Bruno S., Fais F. 

Keywords: Chronic Lymphocityc Leukemia, immunoglobulins, NGS, apoptosis, proliferation 

Analysis of the intracellular signaling cross-talks induced by microenvironmental stimuli modulating aggressiveness and development of relapse/refractory subclones in Chronic Lymphocytic Leukemia patients

Scientists: Mazzarello A.N.

Keywords: Chronic Lymphocytic Leukemia, BCR, TLR9, CD40, Bruton Tyrosine Kinase

Development of methods of oncolytic immunovirotherapy. Assays of oncolytic Herpes Virus retargeted to tumor surface molecules and expressing stimulatory cytokines to induce anti-tumor immune response in mouse models of high grade gliomas

Scientists: Malatesta P. 

Keywords: virotherapy, glioblastoma, oncology 

Analysis of the molecular mechanisms underlying glioma cells invasion and analysis of the immune escape mechanisms of glioma cells in a murine model of glioma progression  

Scientists: Appolloni I., Ceresa D.,  Malatesta P. 

Keywords: glioblastoma, immune escape, cancer

In vitro and in vivo analysis of the effectiveness of photo- and sono-dynamic therapies in gliomas using recombinant phages as vectors to transport light- or ultrasound-activatable sensitizing molecules

Scientists: Appolloni I.

Keywords: glioblastoma, phototherapy, sonotherapy

Study of intratumoral competition at clonal scale and identification of nongenetic mechanisms underlying intraclonal variability in Glioblastoma

Scientists: Ceresa D., Malatesta P. 

Keywords: glioblastoma, cell-cell competition, epigenetics, scRNAseq

Role of non-coding RNAs in the differentiation and metastatic process of neuroblastoma and in vitro/in vivo drug induction of the over-expression of the non-coding RNA NDM29 and development of a drug combination for the treatment of high-risk neuroblastoma 

Scientists:  Pagano A.  

Keywords: non-coding RNAs, neuroblastoma

Identification of glial cell subpopulations in tumors of the parasympathetic nervous system with single cell sequencing strategies. Study of their role in the maintenance of tumor growth

Scientists:  Pagano A.  

Keywords: glial cells

Evaluation and analysis of chemotherapy potentiation in triple negative breast cancer by combined treatments through drug repositioning

Scientists:  Pagano A.  

Keywords: breast cancer

Morpho-functional characterization of molecular mechanisms of antibody-drug conjugates in HER2+ breast cancers and tumor microenvironment 

Characterization of the molecular crosstalk of brain tumor microenvironment and metastatic cells in HER2+ breast cancer

Scientists: Cortese K. 

Keywords: morphology, breast cancer HER2/ERBB2+, antibody-drug conjugates, targeted therapies, autophagy, mitochondrial dynamics, ultrastructure, super resolution imaging

Identification and characterization of tumor associated antigens as target in immunotherapy 

Scientists: Bottino C., Cantoni C., Carlomagno S., Castriconi R., Della Chiesa M., Dondero A., Marcenaro E., Pesce S., Sivori S., Spaggiari G.M. 

Keywords: immunotherapy, ovarian cancer, colo-rectal cancer, pancreatic cancer, hematological malignancies 

Development of in vitro model of multiple mieloma and novel drug development

Personale coinvolto: Tavella S.

Parole chiave:  γδ T cells, ADC, plasmacells, bone marrow