Study of onset, progression and treatment of hematological and solid tumors, focusing on chronic lymphocytic leukemia, glioma, neuroblastoma, colorectal, pancreatic, ovarian and breast cancer

The adaptive immune system is composed by B and T lymphocytes, responsible for the humoral and cell-mediated mediated adaptive immune response. Their receptor is generated by the somatic recombination developing the diversity necessary to respond virtually to any foreign antigen

Glycosylation is the post-translational modification of proteins that gives the most variability to them. The glycosylation of proteins is a very complex process that involves a great number of enzymes and reactions. Moreover, glycosylation is involved in many processes of cell life from signaling to single enzyme activity. The study of protein glycosylation can give important information to understand many cellular processes and to develop new therapeutic approaches