Stem cell biology: paracrine activity and extracellular vesicles

Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. The paracrine activity is mediated by the cell secretome, intended as the mix of protein factors and extracellular vesicles, released by different types of fetal and adult stem/progenitor cells


Paracrine potential of the amniotic fluid-derived stem cell secretome, and in particular extracellular vesicles, for cardiac regeneration/repair and stimulation of the endogenous regenerative mechanisms of the heart 


Scientists:  Bollini S. 

Keywords:  stem cells, extracellular vesicles, heart, endogenous regeneration


Culture of adult stem cells in specific bioreactors, characterization of their secretome and study of extracellular vesicles released by induced pluripotent cells (iPS) 


Scientists: Gentili C. 

Keywords: bioreactors, stem cells, induced pluripotent stem cells, extracellular vesicles


Extracellular Vesicles released from mesenchymal stem cells grown under different conditions and evaluation of their anti-inflammatory potential in the context of inflammaging 


Scientists: Tasso R.  

Keywords: stem cells, extracellular vesicles, inflammaging


Surface modification using bioactive molecules for the trapping of mesenchymal stem cells or as a mimicry of the articular cartilage microenvironment 


Scientists: Giannoni P. 

Keywords: stem cells, articular cartilage


Study of the microenvironment for the maintenance of stemness by bone marrow mesenchymal stem cells (BMSC), and evaluation of the role of the role of BMSC secretome in the neoplastic microenvironment, with particular focus on chronic lymphatic leukemia 


Scientists:  Giannoni P., Quarto R. 

Keywords:  secretome, extracellular vesicles, stem cells


Last update 8 July 2022