Stem cells have emerged as a key element of regenerative medicine therapies due to their inherent ability to differentiate into a variety of cell phenotypes, thereby providing numerous potential cell therapies to treat an array of degenerative diseases and traumatic injuries. A recent paradigm shift has emerged suggesting that the beneficial effects of stem cells may not be restricted to cell restoration alone, but also due to their transient paracrine actions. The paracrine activity is mediated by the cell secretome, intended as the mix of protein factors and extracellular vesicles, released by different types of fetal and adult stem/progenitor cells
Paracrine potential of the amniotic fluid-derived stem cell secretome, and in particular extracellular vesicles, for cardiac regeneration/repair and stimulation of the endogenous regenerative mechanisms of the heart
Scientists: Bollini S.
Study of the microenvironment for the maintenance of stemness by bone marrow mesenchymal stem cells (BMSC), and evaluation of the role of the role of BMSC secretome in the neoplastic microenvironment, with particular focus on chronic lymphatic leukemia