Cell metabolism is the whole of pathways involved in cell life from signalling to energy production. The assessment of energy metabolism dynamics according to energy needs and the microenvironment is a key aspect to be considered in studying the biology of aging, cancer, and other pathologies. The study of metabolism could give us important information about the physiopathology of cells and can help to find new therapeutic approaches for different pathologies
Evaluation of bioenergetics, energy metabolism, mitochondrial biogenesis, and dynamics in physiological and pathological conditions, such as aging, cancer, and hematological disorders
Scientists: Ravera S.
Identification of metabolic markers to characterize and treat early aging associated with chemo- and radiotherapy in childhood cancer survivors
Scientists: Ravera S.
Investigation of the role of NAD (fundamental coenzyme in energy production and regulator of various processes) in different physio-pathological conditions (including aging, cancer, neurodegenerative conditions), in order to identify new therapeutic approaches acting on NAD synthesis pathways (mediated by NAMPT or NAPRT) or NAD signalling pathways (mediated by CD38 and sirtuins) of NAD
Scientists: Bruzzone S., Piacente F., Benzi A.
Identification of differential expression of calpastatin splicing forms and their role in human pathologies involving alteration in Ca2+-homeostasis. Investigation on the correlations among the various components of the calpain/calpastatin system, focusing on the role of the common regulatory subunit of calpains in cancer cells
Scientists: De Tullio R.
Study of new factors involved in the development of white and brown adipose tissue and metabolic programming
Scientists: Sturla L.
Investigation on the dependence of CLL cells on glucose and lipid metabolism for the control of apoptosis, cell activation and proliferation. Identification of related targeted therapies
Scientists: Bruno S.
Investigating the key role of the Pentose Phosphate Pathway as a metabolic regulator of reducing power (NADPH) and intracellular signaling, which drives proliferation, aggressiveness, and resistance to anti-Bcl2 therapy in Chronic Lymphocytic Leukemia B-cells
Scientists: Cossu V., Mazzarello AN., Bruno S.
Investigation of the contribution of redox balance and antioxidant responses in the development of T lymphocyte and CART exhaustion in lymphoma patients
Scientists: Cossu V., Mazzarello AN., Bruno S.