To study physiologically relevant in vitro 3D models as platforms for a dynamic comprehension of physiopathology, providing a more reliable model in “drug discovery” that mimics the in vivo tissue morphology and microenvironment
Assessment of in vitro 3D models, using fluidic bioreactors and/or retinal organoids for the study of mechanisms underlying glaucomatous neurodegeneration, to identify preventive and therapeutic strategies.
Scientists: Penco S., Tirendi S., Vernazza S.
Biological functions and effects of magnetoelectric nanoparticles activated by magnetic fields (MENPs) on mesenchymal and/or colorectal cancer cells in 2D and 3D cell culture systems, with the aim of optimizing and enhancing the potential application of MENPs as systems for the identification and localized eradication of micrometastases
Scientists: Giannoni P.
Static and fluidic 3D models for studying NK cells/neuroblastoma interactions and novel immunotherapeutics based on NK cell engagers
Scientists: Bottino C., Castriconi R., Dondero A.
Study of the interaction and efficacy of engineered nanoparticles on patient-specific three-dimensional organoids of metastatic colorectal carcinoma under static and dynamic culture conditions
Scientists: Tasso R.
Development of 3D culture system through the use of tools that mimic microgravity and bioreactors for dynamic cultures
Scientists: Tavella S.
Development of 3D models: spheroids, organoids and 3D bioprinting applied to the study of breast cancer and osteosarcoma
Scientists: Gentili C.
Development and high-resolution analysis of 3D spheroid models of HER2-positive and HER2-low breast cancer to study ADC penetration, response and resistance, and morphological rewiring under therapy pressure
Personale coinvolto: Cortese K.
Development and application of innovative 3D microfluidic platforms aimed at studying chemoresistance processes in cutaneous melanoma
Personale coinvolto: Domenicotti C., Marengo B.