Molecular mechanisms of drug sensitivity and resistance

Cancer treatments are nowadays quite effective in the first istance, but very often recurrent resistance phenomena arise with inauspicious prognostic outcomes. Study the adaptive cellular responses and the molecular mechanisms induced by short- and long-term treatments with anticancer drugs in different human cancer cells is useful in order to identify new potential molecular targets.


 

To study the molecular mechanisms underlying the cellular responses induced by anticancer drugs in human neuroblastoma and melanoma cells

Scientists: Furfaro A.L., Nitti M.

Keywords: redox balance, heme oxygenase-1, Nrf2, BRAF-V600


 

To study the molecular mechanisms underlying therapy resistance in homemade-resistant human neuroblastoma and melanoma cells

 

Scientists: Domenicotti C., Marengo B., Traverso N.

Keywords: redox balance, glutathione, oxidative metabolism, microRNA


 

To develop protocols of tertiary chemo-prevention to prevent cancer recurrence and the onset of chemo/radio resistance

Scientists: Izzotti A.

Keywords: cancer, epigenetic, microRNA, relapse prevention, oncology, drugs


 

 

 

 
Last update 8 July 2022