Analysis of proteins structure and their modifications by different technical approaches to support the discovery of new functions and drug targets
Proteomic analysis and structural characterization of post-translational modifications (PTMs) by means of medium and high-resolution mass spectrometry techniques (MS and MS/MS). Metabolomic analysis and structural characterization of primary and secondary metabolites from plant and animal sources by mean of gas chromatography and/or liquid chromatography coupled to mass spectrometric techniques (GC-MS) (HPLC-ESI-MS)
Scientists: Damonte G.
Structural and functional characterization of the human receptors for abscisic acid LANCL2 and LANCL1, novel drug targets in the treatment of prediabetes and the metabolic syndrome; study of the metabolic and behavioural phenotype of a LANCL2 knock out mouse strain
Identification and characterization of new leukocyte biomarkers related to the drug-mediated recovery of functional CFTR in cystic fibrosis and the study of polyphenolic antioxidant molecules extracted from olive pomace with neuronal-protective action under stress conditions caused by the alteration of intracellular calcium homeostasis
Scientists: Averna M.
Use of statistical and informatics tools in the analysis of Genomics, Proteomics, Metabolomics, and Lipidomics data to support medical research, for effective stratification of patients, evaluation of risk factors, monitoring of therapeutic treatments, determination of biochemical pathways and biological processes involved in the homeostasis of health state and progression of patient's diseases
Personale coinvolto: Bruschi M.