Protein science and proteomics

Analysis of proteins structure and their modifications by different technical approaches to support the discovery of new functions and drug targets


Proteomic analysis and structural characterization of post-translational modifications (PTMs) by means of medium and high-resolution mass spectrometry techniques (MS and MS/MS). Metabolomic analysis and structural characterization of primary and secondary metabolites from plant and animal sources by mean of gas chromatography and/or liquid chromatography coupled to mass spectrometric techniques (GC-MS) (HPLC-ESI-MS)     

Scientists:  Damonte G. 

Keywords:  structural characterization, HPLC, mass spectrometry 


Exploiting particular nanotechnologies, Langmuir-Blodgett (LB) deposition and Quartz Crystal Microbalance (QCM), to be used both in basic research and in different areas of technology

Scientists:  Pechkova E. 

Keywords:  nanocrystallography, Langmuir-Blodgett, synchrotron radiation


Structural and functional characterization of the human receptors for abscisic acid LANCL2 and LANCL1, novel drug targets in the treatment of prediabetes and the metabolic syndrome; study of the metabolic and behavioural phenotype of a LANCL2 knock out mouse strain

Scientists:  Zocchi E., Sturla L. 

Keywords:  LANCL receptors, metabolic syndrome, drug design


Identification and characterization of new leukocyte biomarkers related to the drug-mediated recovery of functional CFTR in cystic fibrosis and the study of polyphenolic antioxidant molecules extracted from olive pomace with neuronal-protective action under stress conditions caused by the alteration of intracellular calcium homeostasis

Scientists:  Averna M. 

Keywords:  CFTR, cystic fibrosis, calcium-dependent regulation, waste valorization, biomarkers 


Use of statistical and informatics tools in the analysis of Genomics, Proteomics, Metabolomics, and Lipidomics data to support medical research, for effective stratification of patients, evaluation of risk factors, monitoring of therapeutic treatments, determination of biochemical pathways and biological processes involved in the homeostasis of health state and progression of patient's diseases

Personale coinvolto:  Bruschi M.

Parole chiave: bioinformatics, statistics, machine learning, cluster analysis

Last update 25 January 2023