The project aims to investigate the physiopathological roles of a class of emerging genes causative for neuronal functional and morphological alterations that impact on cellular development, synaptic function and behavior. The activities related to this research topic are the study of proteins involved in the physiopathological mechanisms that regulate synaptic vesicle biogenesis, trafficking and degradation and the impact of dysregulation of presynaptic physiology in brain disorders
Characterization of the molecular and electrophysiological mechanisms of human mutations in synaptic genes causative of autism and epilepsy
Scientists: Baldelli P., Benfenati F., Corradi A., Fassio A., Michetti C., Onofri F.
Keywords: epileptogenesis, synapsins, autism, hyperexcitability, behavioral phenotype
Role of proteins that regulate pH homeostasis and autophagy in the regulation of neuronal development and synaptic vesicle trafficking
Roles of the dysregulation of endocytic pathways and autophagy in developmental encephalopathy with epilepsy
Scientists: Benfenati F., Corradi A., Fassio A., Giovedi S., Michetti C.
Keywords: live-imaging, autophagy, neurodevelopment, neurodegeneration, synaptic vesicles
Role of LRKK2 in synaptic vesicle trafficking and neurotransmitter release in Parkinson’s disease
Scientists: Benfenati F., Marte A., Onofri F.
Keywords: LRRK2, Parkinson’s disease, synapsins, synaptic vesicles, phosphorylation
Role of APache in neuronal development, synaptic functions and implications for Alzheimer’s disease
Scientists: Benfenati F., Giovedì S.
Keywords: APache, autophagy, Alzheimer’s disease, neurodevelopment, synaptic vescicles
Neuroinflammation and synaptic plasticity
Scientists: Benfenati F., Valente P.
Keywords: ion channels, neuroinflammation, TRP channels, pain, calcium
Mechanisms and applications of hypoglycemic diet in preventing epileptogenesis in experimental models of epilepsy
Scientists: Baldelli P., Benfenati F., Michetti C.
Keywords: hypoglycaemic diet, multi-electrode array electrophysiology (MEA), behavioral phenotype
Role of the Alzheimer’s disease-associated Ab peptide in the process of memory formation
Antiproliferative strategies to improve the outcome of glaucoma surgery
Scientists: Ricciarelli R.
Keywords: Alzheimer’s disease, amyloid-β, Tau, neurodegeneration, glaucoma, Tenon’s fibroblasts
Roles of the dysregulation of autophagy and extracellular vesicle release in TDP-43-mediated toxicity in amyotrophic lateral sclerosis (ALS) in vitro and in vivo models
Scientists: Cortese K.
Keywords: live-imaging, autophagy, electron microscopy, neurodegeneration, TDP-43