Synaptic homeostasis and plasticity

The research is based on the study of the physiological mechanisms that underlie the neuronal functions in terms of synaptic properties, transmission, activity-dependent plasticity and intrinsic excitability. These properties are investigated in neurons as single cells or organized in microcircuits using a variety of electrophysiological, imaging and biochemical experimental techniques


Characterization of the molecular and electrophysiological role of the neuron-restrictive silencer factor/repressor element 1 (RE1)-silencing transcription factor (NRSF/REST)


Scientists:  Baldelli P., Benfenati F., Valente P.

Keywords:  NRFS/REST, homeostatic plasticity, synaptic transmission, neuronal circuitry


Role of Proline-rich transmembrane protein 2 (PRRT2) in neurotransmission and synaptic homeostatic plasticity

Identification of molecular determinants of PPRT2 protein function


Scientists:  Baldelli P., Benfenati F., Casagrande S., Corradi A., Fassio A., Michetti C., Valente P.

Keywords:  PRRT2, neurotransmitters release, neuronal excitability, synaptic proteins, structure-function relationship


Last update 8 July 2022