The research is based on the study of the physiological mechanisms that underlie the neuronal functions in terms of synaptic properties, transmission, activity-dependent plasticity and intrinsic excitability. These properties are investigated in neurons as single cells or organized in microcircuits using a variety of electrophysiological, imaging and biochemical experimental techniques
Characterization of the molecular and electrophysiological role of the neuron-restrictive silencer factor/repressor element 1 (RE1)-silencing transcription factor (NRSF/REST)
Scientists: Baldelli P., Benfenati F., Dionisi M., Onofri F., Valente P.
Keywords: NRFS/REST, homeostatic plasticity, synaptic transmission, neuronal circuitry
Role of Proline-rich transmembrane protein 2 (PRRT2) in neurotransmission and synaptic homeostatic plasticity
Identification of molecular determinants of PPRT2 protein function
Scientists: Baldelli P., Benfenati F., Casagrande S., Corradi A., Fassio A., Michetti C., Valente P.
Keywords: PRRT2, neurotransmitters release, neuronal excitability, synaptic proteins, structure-function relationship