The tumor microenvironment is an important modulator of malignant growth. A deep understanding of the complex relationships occurring at the tumor site among stromal cells, immune cells, and soluble factors could provide important information on the recruitment of immune cells and the possible impairment of their anti-tumor properties. Elucidating the complex network in the tumor microenvironment can be crucial for understanding the mechanisms of tumor escape from immune recognition, and for developing new therapeutic strategies
Analysis of the role of NK/ILCs, dendritic cells and CD8+ T cells in different tumors occurring in adult (melanoma, lung, gastric, ovarian, endometrial, breast, pancreatic, and colon-rectal) or pediatric (neuroblastoma, Wilms’ tumor, leukemia) patients
Scientists: Bottino C., Cantoni C., Carlomagno S., Castriconi R., Della Chiesa M., Dondero A., Marcenaro E., Ferlazzo G., Marcenaro E., Pesce S., Pietra G., Sivori S., Spaggiari G.M., Vitale C.
Keywords: NK cells, anti-tumor response, tumor microenvironment, solid tumors, multiparametric flow cytometry
Analysis of the macrophage population in various adult tumors (gastric, ovarian, endometrial, pancreatic, and colorectal), in pediatric tumors (neuroblastoma), and in the context of pulmonary diseases
Scientists: Bottino C., Castriconi R., Dondero A.
Keywords: NK cells, anti-tumor response, tumor microenvironment, solid tumors, multiparametric flow cytometry